Data Integrity is one of the most important areas of consideration for clinical development these days where the use of technology support is being increasingly adopted. FDA investigators continue to cite a significant number of data integrity observations during inspections. There has also been an increase in regulators taking action against data fraud or false information. They are keeping pressure on those with data integrity shortcomings, issuing a growing number of warning letters and FDA-483s every year for the last few years. With a great change in the digital landscape for clinical development, it would be ideal for the Clinical Data Management community to discuss and understand more about the opportunities and challenges of fundamental Data integrity principles being implemented in the new digital world of affairs.