Our theme for the first virtual SDE is highly relevant during the COVID-19 scenario, when the whole world is struggling to manage through the pandemic. Our industry is also suffering with 70%-80% of sites inaccessible or only having restricted or proscribed access for monitoring visits. Many sites are also focused on COVID-19 care with less staff availability to help with ongoing studies and patients not able to travel to sites for study visit appointments. Remote monitoring, at-home lab draws, telehealth visits, and the virtual trial platform are becoming more important these days as times are changing. The impact of the pandemic may result in a change in the way we live in the future; therefore, understanding the capabilities, technology and opportunities on virtual possibilities of conducting clinical trials by ensuring the Design, Conduct, Monitoring and Analysis enables adapting to this paradigm. It thus is a great opportunity for all to be part of this SDE to broaden our knowledge as clinical research professionals.